In year of 2017
[13] CUT-PCR: CRISPR-mediated, Ultra-sensitive Detection of Target DNA using PCR.
Seung Hwan Lee, Jihyeon Yu, Gue-Ho Hwang, Sojung Kim, Heon Seok Kim, Kyoungmi Kim, Juhee Park, Do Youn Park, Yoon-Kyoung Cho, Jin-Soo Kim, and Sangsu Bae,
Oncogene, 2017, Aug, 28 (36), 6823-6829
[12] Multi-color fluorescence of pNIPAM-Based nanogels modulated by dual stimuli - responsive FRET processes.
Seung Hwan Lee*, Hoa Thi Bui*,Temmy Pegarro Vales, Sung Cho, Ho-Joong Kim,
Dyes and Pigments, 2017, June, 3, 145, 216-221.
[11] Fabrication of Photochromic Hydrogels Using an Interpenetrating Chitosan Networks for Controlled Drug Delivery.
Cheol Woo Lee*, Seung Hwan Lee*, Young-Keun Yang*, Geun-Chang Ryu and Ho-Joong Kim,
Journal of Applied Polymer Science, 2017, Mar, 30, 134(30). 45120-45126. (Co-first author)
[10] Failure to detect DNA-guided genome editing using Natronobacterium gregoryi Argonaute.
Seung Hwan Lee*, Giandomenico Turchiano*, Hirotaka Ata*, Somaira Nowsheen, Marianna Romito, Zhenkun Lou, Seuk-Min Ryu, Stephen C. Ekker, Toni Cathomen, Jin-Soo Kim,
Nature biotechnology, 2017, Jan, 35(1), 17-18.
[9] Light-Induced Fluorescence Modulation of Quantum Dot-Crystal Violet Conjugates: Stochastic Off-On-Off Cycles for Multi-Color Patterning and Super-Resolution.
Sungwook Jung, Joonhyuck Park, Jiwon Bang, Jae-Yeol Kim, Cheolhee Kim, Yongmoon Jeon, Seung Hwan Lee, Ho Jin, Sukyung Choi, Bomi Kim, Woo Jin Lee, Chan-Gi Pack, Jong-Bong Lee, Nam Ki Lee, and Sungjee Kim,
JACS, 2017, May, 139(22), 7603–7615.
[8] Myofibroblast in the Ligamentum Flavum Hypertrophic Activity.
Junseok W. Hur, Taegeun Bae, Sunghyeok Ye, Joo-Hyun Kim, Sunhye Lee, Kyoungmi Kim, Seung Hwan Lee, Jin-Soo Kim, Jang-Bo Lee, Tai-Hyoung Cho, Jung-Yul Park, Junho K. Hur,
European Spine Journal, 2017, Feb, 8, 26(285): 1-10.
[7] Genome surgery using Cas9 ribonucleoproteins for the treatment of age-related macular degeneration.
Kyoungmi Kim, Sung Wook Park, Jin Hyoung Kim, Seung Hwan Lee, Daesik Kim, Taeyoung Koo, Kwang-eun Kim, Jeong Hun Kim, Jin-Soo Kim,
Genome Research, 2017, February 16, 27:419-426.
[6] The bent conformation of poly(A)-binding protein induced by RNA-binding is required for its translational activation function.
Ka Young Hong, Seung Hwan Lee, Sohyun Gu, Eunah Kim, Sihyeon An, Junyoung Kwon, Jong-Bong Lee, Sung Key Jang,
RNA biology, 2017, Mar 4;14(3):370-377.
In year of 2019
[20] Specificity Assessment of CRISPR Genome Editing of Oncogenic EGFR Point Mutation with Single-Base Differences.
Taegeun Bae#, Hanseop Kim#, Jeong Hee Kim, Yong Jun Kim, Seung Hwan Lee*, Byung-Joo Ham* and Junho K. Hur,
Molecules, 2019, Dec, 25,52 (Co-correspondence)
[19] CRISPR Diagnostics and Therapeutics with Single Base-Pair Precision.
Seung Hwan Lee*, Young-Ho Park, Yeung Bae Jin, Sun-Uk Kim, Junho K Hur*,
Trends in Molecular Medicine, 2019, Nov, 26(3), 337-350 (Co-correspondence)
[18] Comparative evaluation of hormones and hormone-like molecule in lineage specification of human induced pluripotent stem cells.
Seon-A Choi*, Ju-Hyun An*, Seung Hwan Lee*, Geun-Hui Lee, Hae-Jun Yang, Pil-Soo Jeong, Jae-Jin Cha, Sanghoon Lee, Young-Ho Park, Bong-Seok Song, Bo-Woong Sim, Young-Hyun Kim, Ji-Su Kim, Yeung Bae Jin, Jae-Won Huh, Sang-Rae Lee, Jong-Hee Lee, Sun-Uk Kim,
International Journal of Stem Cells, 2019, 12(2), eISSN 2005-5447. (Co-first author)
[17] Real-time PCR quantification of spliced X-box binding protein 1 (XBP1) using a universal primer method,
Seung-Bin Yoon, Young-Ho Park, Seon-A Choi, Hae-Jun Yang, PilSoo Jeong, Jae-Jin Cha, Sanghoon Lee, Seung Hwan Lee, Jong-Hee Lee, BoWoong Sim, Bon-Sang Koo, Sang-Je Park, Youngjeon Lee, Young-Hyun Kim, Jung Joo Hong, Ji-Su Kim, Yeung Bae Jin, Jae-Won Huh, Sang-Rae Lee, BongSeok Song, Sun-Uk Kim,
PLoS One, 2019, 14(7)
In year of 2018
[16] CRISPR/Cas9 searches for a protospacer adjacent motif by lateral diffusion.
Viktorija Globyte#, Seung Hwan Lee#, Taegeun Bae, Jin‐Soo Kim, Chirlmin Joo*,
The EMBO Journal, 2018, Dec, 20. 38(4) e99466. (Co-first author)
[15] CRISPR and Target-Specific DNA Endonucleases for Efficient DNA Knock-in in Eukaryotic Genomes.
Seung Hwan Lee*, Sunghyun Kim, and Junho K Hur*,
Mol. Cells, 2018; 41(11): 943-952. (Co-correspondence)
[14] Direct observation of DNA target searching and cleavage by CRISPR-Cas12a.
Yongmoon Jeon, You Hee Choi, Yunsu Jang, Jihyeon Yu, Jiyoung Goo, Gyejun Lee, You Kyeong Jeong, Seung Hwan Lee, In-San Kim, Jin-Soo Kim, Cherlhyun Jeong, Sanghwa Lee & Sangsu Bae,
Nature Communications, 2018, July 17, volume 9(2777).
In year of 2025
[40] Directed evolution on compact landing pads yields highly-efficient recombinases for large DNA integration, 2025, Nucleic Acids Research
Hanseop Kim, Hyo-Gu Kang, Yeounsun Oh, Youngjeon Lee, Eun-Kyoung Kim, Ki-Hoan Nam, Dong-Seok Lee, Seung Hwan Lee* and Bo-Woong Sim*
[39] Ultrasensitive single-point mutation detection via digital counting of individual dCas9-DNA complexes, 2025, Sensors and Actuators B: Chemical
Seohyun Kim, Wi-jae Lee, Hyomin K. Lee, Sangmin Ji, Junho K. Hur*, Seung Hwan Lee*, Hye Ran Koh*
[38] Optimizing twin prime editing components for scalable genome editing and therapy in spinocerebellar ataxia type 3
Lee Wha Gwon, Jung Bae Seong, Hyeon-Gu Yeo, Yeounsun Oh, Junghyung Park, Jinyoung Won, Sang Je Park, Young-Hyun Kim, Jae-won Huh, Aryun Kim, Youngjeon Lee*, Seung Hwan Lee*
[37] Precise Progerin Targeting Using RfxCas13d: A Therapeutic Avenue for Hutchinson–Gilford Progeria Syndrome, 2025, Molecular Therapy
Unbin Chae †, Hae-Jun Yang †, Hanseop Kim†, Seung Hwan Lee†, Dong Gil Lee, Jeong Young Koo, Seung-min Ha, Seo-Jong Bak, Jin-Man Kim#, Young-Ho Park#, Sun-Uk Kim#
[36] Advances in large-scale DNA engineering with RNA-guided endonucleases, 2025, Experimental & Molecular Medicine
Lee Wha Gwon*, Isabel Wen Badon*, Youngjeon Lee, Ho-Joong Kim#, Seung Hwan Lee#
[35] Optimized and tunable base editing in human-derived cells using an inactivated Cas12b effector, 2025
Wi-jae Lee*, Yun Gyeong Kim*, Yeounsun Oh*, Ho-Joong Kim*, Bo-Woong Sim*, Seung Hwan Lee*
In year of 2026
High-fidelity CRISPR genome editing of single-nucleotide mutation with near-complementary guide RNA via enhanced target binding kinetics
Hyomin K Lee, Seohyun Kim, Hyeon Jong Yu, Juyoung Hong, Taegeun Bae, Yohan An, Chang Ho Sohn, Woo Chang Hwang, Chul-Kee Park*, Seung Hwan Lee*, Hye Ran Koh*, Junho K Hur*
In year of 2025
[40] Directed evolution on compact landing pads yields highly-efficient recombinases for large DNA integration, 2025, Nucleic Acids Research
Hanseop Kim, Hyo-Gu Kang, Yeounsun Oh, Youngjeon Lee, Eun-Kyoung Kim, Ki-Hoan Nam, Dong-Seok Lee, Seung Hwan Lee* and Bo-Woong Sim*
[39] Ultrasensitive single-point mutation detection via digital counting of individual dCas9-DNA complexes, 2025, Sensors and Actuators B: Chemical
Seohyun Kim, Wi-jae Lee, Hyomin K. Lee, Sangmin Ji, Junho K. Hur*, Seung Hwan Lee*, Hye Ran Koh*
[38] Optimizing twin prime editing components for scalable genome editing and therapy in spinocerebellar ataxia type 3
Lee Wha Gwon, Jung Bae Seong, Hyeon-Gu Yeo, Yeounsun Oh, Junghyung Park, Jinyoung Won, Sang Je Park, Young-Hyun Kim, Jae-won Huh, Aryun Kim, Youngjeon Lee*, Seung Hwan Lee*
[37] Precise Progerin Targeting Using RfxCas13d: A Therapeutic Avenue for Hutchinson–Gilford Progeria Syndrome, 2025, Molecular Therapy
Unbin Chae †, Hae-Jun Yang †, Hanseop Kim†, Seung Hwan Lee†, Dong Gil Lee, Jeong Young Koo, Seung-min Ha, Seo-Jong Bak, Jin-Man Kim#, Young-Ho Park#, Sun-Uk Kim#
[36] Advances in large-scale DNA engineering with RNA-guided endonucleases, 2025, Experimental & Molecular Medicine
Lee Wha Gwon3,4,*, Isabel Wen Badon1,5,*, Youngjeon Lee3,4, Ho-Joong Kim2,#, Seung Hwan Lee1,#
[35] Optimized and tunable base editing in human-derived cells using an inactivated Cas12b effector, 2025
Wi-jae Lee*, Yun Gyeong Kim*, Yeounsun Oh*, Ho-Joong Kim†, Bo-Woong Sim*, Seung Hwan Lee*
In year of 2024
[34] CdSe Quantum Dot-Based Delivery System for CRISPR-Cas9 Mediated Microglial Gene Modulation, 2024, ACS Applied Nano Materials, Cover
Hyeon-Gu Yeo†, Jinyoung Won†, Lee Wha Gwon†, Seokbeom Roh, Wi-Jae Lee, Kyung Seob Lim, Chang-Yeop Jeon, Junghyung Park, A Reum JE, Jincheol Seo, Jiyeon Cho, Jung Bae Seong, Yu Gyeong Kim, Keonwoo Kim, Sang-Woo Lee, Sung-hyun Park, Won Seok Choi, Yang Hoon Huh, Gyudo Lee, Hyoung-Chin Kim, Seung Hwan Lee*, Youngjeon Lee**
[33] Blood vessel organoids generated by base editing and harboring single nucleotide variation in Notch3 effectively recapitulate CADASIL-related pathogenesis, 2024, Molecular Neurobiology
Yujin Ahn, Ju-Hyun An, Hae-Jun Yang, Wi-Jae Lee, Sang-Hee Lee, Young-Ho Park, Jong-Hee Lee, Hong J. Lee, Seung Hwan Lee*, Sun-Uk Kim*
[32] Tiny CRISPR Molecular Switch Tool Opens a New World, 2024, Molecular Therapy
Yeounsun Oh# & Seung Hwan Lee*
[31] Highly efficient and specific regulation of gene expression using enhanced CRISPR-Cas12f system, 2024, Gene Therapy
Yeounsun Oh, Kee-Pyo Kim* and Seung Hwan Lee*
[30] Recent application of CRISPR-Cas12 and OMEGA system for genome editing, 2023, Molecular Therapy
Isabel Wen Badon, Yeounsun Oh, Ho-Joong Kim*, Seung Hwan Lee*
[29] Recent advances in genome engineering by CRISPR technology, 2024, BMB Reports
Youngsik Lee#, Yeounsun Oh# & Seung Hwan Lee*
[28] Utilization of nicking properties of CRISPR-Cas12a effector for genome editing, 2024, Scientific Reports
Chan Hyoung Kim, Wi-jae Lee, Yeounsun Oh, Youngjeon Lee, Hyomin K. Lee, Jung Bae Seong, Kyung-Seob Lim, Sang Je Park, Jae-Won Huh, Young-Hyun Kim, Kyoung Mi Kim*, Junho K. Hur* and Seung Hwan Lee*
In year of 2022-2023
[27] Highly specific chimeric DNA-RNA guided genome editing with enhanced CRISPR-Cas12a system
Hanseop Kim#, Wi-jae Lee#, Chan Hyoung Kim, Yeounsun Oh, Lee Wha Gwon, Hyomin Lee, Woo Jeung Song, Junho K. Hur, Kyung-Seob Lim, Kang Jin Jeong, Ki-Hoan Nam, Young Suk Won, Kyeong-Ryoon Lee, Youngjeon Lee, Young-Hyun Kim, Jae-Won Huh, Bong-Hyun Jun*, Dong-Seok Lee*, Seung Hwan Lee*,
Molecular Therapy - Nucleic Acids, 2022, June, 28, 353-362.
[26] Expansion of the prime editing modality with Cas9 from Francisella novicida.
Yeounsun Oh#, Wi-jae Lee#, Junho K. Hur#, Woo Jeung Song, Hanseop Kim, Lee Wha Gwon, Young-Hyun Kim, Young-Ho Park, Chan Hyoung Kim, Kyung-Seob Lim, Jae-Won Huh, Sun-Uk Kim, Bong-Hyun Jun, Cheulhee Jung*, Seung Hwan Lee*,
Genome Biology, 2022, April, 23, 92 (2022). https://doi.org/10.1186/s13059-022-02644-8.
In year of 2021
[25] Development of CRISPR technology for precise single-base genome editing: a brief review.
Hyomin K. Lee#, Yeounsun Oh#, Juyoung Hong, Seung Hwan Lee*, Junho K. Hur*,
BMB Reports, 2021, Feb, 54(2):98-105
[24] Peroxiredoxin-6 regulates p38-mediated epithelial–mesenchymal transition in HCT116 colon cancer cells
Unbin Chae, Bokyung Kim, HanSeop Kim, Young‑Ho Park, Seung Hwan Lee, Sun‑Uk Kim and Dong‑Seok Lee,
Journal of Biological Research-Thessaloniki, 2021, 2021 Nov 23;28(1):22.
Selected Publication
[40] Directed evolution on compact landing pads yields highly-efficient recombinases for large DNA integration, 2025, Nucleic Acids Research
Hanseop Kim, Hyo-Gu Kang, Yeounsun Oh, Youngjeon Lee, Eun-Kyoung Kim, Ki-Hoan Nam, Dong-Seok Lee, Seung Hwan Lee* and Bo-Woong Sim*
[36] Advances in large-scale DNA engineering with RNA-guided endonucleases, 2025, Experimental & Molecular Medicine
Lee Wha Gwon*, Isabel Wen Badon*, Youngjeon Lee, Ho-Joong Kim#, Seung Hwan Lee#
[30] Recent application of CRISPR-Cas12 and OMEGA system for genome editing, 2023, Molecular Therapy
Isabel Wen Badon, Yeounsun Oh, Ho-Joong Kim*, Seung Hwan Lee*
[27] Highly specific chimeric DNA-RNA guided genome editing with enhanced CRISPR-Cas12a system, Molecular Therapy - Nucleic Acids, 2022, June, 28, 353-362.
Hanseop Kim#, Wi-jae Lee#, Chan Hyoung Kim, Yeounsun Oh, Lee Wha Gwon, Hyomin Lee, Woo Jeung Song, Junho K. Hur, Kyung-Seob Lim, Kang Jin Jeong, Ki-Hoan Nam, Young Suk Won, Kyeong-Ryoon Lee, Youngjeon Lee, Young-Hyun Kim, Jae-Won Huh, Bong-Hyun Jun*, Dong-Seok Lee*, Seung Hwan Lee*
[26] Expansion of the prime editing modality with Cas9 from Francisella novicida, Genome Biology, 2022, April, 23, 92 (2022).
Yeounsun Oh#, Wi-jae Lee#, Junho K. Hur#, Woo Jeung Song, Hanseop Kim, Lee Wha Gwon, Young-Hyun Kim, Young-Ho Park, Chan Hyoung Kim, Kyung-Seob Lim, Jae-Won Huh, Sun-Uk Kim, Bong-Hyun Jun, Cheulhee Jung*, Seung Hwan Lee*,
[23] Enhancement of Target Specificity of CRISPR-Cas12a by Using a Chimeric DNA-RNA Guide, Nucleic Acids Research, 2020, Sep, 48(15), 8601-8616.
Hanseop Kim#, Wi-jae Lee#, Yeounsun Oh, Seung-Hun Kang, Junho K. Hur, Hyomin Lee, WooJeung Song, Kyung-Seob Lim, Young-Ho Park, Yeung Bae Jin, Bong-Hyun Jun, Cheulhee Jung, Dong-Seok Lee*, Sun-Uk Kim*, and Seung Hwan Lee*
[22] Prediction-based highly sensitive CRISPR off-target validation using target-specific DNA enrichment, Nature communications, 2020, July, 11, 3596 .
Seung-Hun Kang, Wi-jae Lee, Ju-Hyun An, Jong-Hee Lee, Young-Hyun Kim, Hanseop Kim, Yeounsun Oh, Young-Ho Park, Yeung Bae Jin, Bong-Hyun Jun, Junho K Hur*, Sun-Uk Kim* and Seung Hwan Lee*,
[19] CRISPR Diagnostics and Therapeutics with Single Base-Pair Precision, Trends in Molecular Medicine, 2019, Nov, 26(3), 337-350 (Correspondence)
Seung Hwan Lee*, Young-Ho Park, Yeung Bae Jin, Sun-Uk Kim, Junho K Hur*,
[16] CRISPR/Cas9 searches for a protospacer adjacent motif by lateral diffusion, The EMBO Journal, 2018, Dec, 20. 38(4) e99466. (Co-first author)
Viktorija Globyte#, Seung Hwan Lee#, Taegeun Bae, Jin‐Soo Kim, Chirlmin Joo*,
In year of 2022-2023
[27] Highly specific chimeric DNA-RNA guided genome editing with enhanced CRISPR-Cas12a system
Hanseop Kim#, Wi-jae Lee#, Chan Hyoung Kim, Yeounsun Oh, Lee Wha Gwon, Hyomin Lee, Woo Jeung Song, Junho K. Hur, Kyung-Seob Lim, Kang Jin Jeong, Ki-Hoan Nam, Young Suk Won, Kyeong-Ryoon Lee, Youngjeon Lee, Young-Hyun Kim, Jae-Won Huh, Bong-Hyun Jun*, Dong-Seok Lee*, Seung Hwan Lee*,
Molecular Therapy - Nucleic Acids, 2022, June, 28, 353-362.
[26] Expansion of the prime editing modality with Cas9 from Francisella novicida.
Yeounsun Oh#, Wi-jae Lee#, Junho K. Hur#, Woo Jeung Song, Hanseop Kim, Lee Wha Gwon, Young-Hyun Kim, Young-Ho Park, Chan Hyoung Kim, Kyung-Seob Lim, Jae-Won Huh, Sun-Uk Kim, Bong-Hyun Jun, Cheulhee Jung*, Seung Hwan Lee*,
Genome Biology, 2022, April, 23, 92 (2022). https://doi.org/10.1186/s13059-022-02644-8.
In year of 2021
[25] Development of CRISPR technology for precise single-base genome editing: a brief review.
Hyomin K. Lee#, Yeounsun Oh#, Juyoung Hong, Seung Hwan Lee*, Junho K. Hur*,
BMB Reports, 2021, Feb, 54(2):98-105
[24] Peroxiredoxin-6 regulates p38-mediated epithelial–mesenchymal transition in HCT116 colon cancer cells
Unbin Chae, Bokyung Kim, HanSeop Kim, Young‑Ho Park, Seung Hwan Lee, Sun‑Uk Kim and Dong‑Seok Lee,
Journal of Biological Research-Thessaloniki, 2021, 2021 Nov 23;28(1):22.
In year of 2020
[23] Enhancement of Target Specificity of CRISPR-Cas12a by Using a Chimeric DNA-RNA Guide.
Hanseop Kim#, Wi-jae Lee#, Yeounsun Oh, Seung-Hun Kang, Junho K. Hur, Hyomin Lee, WooJeung Song, Kyung-Seob Lim, Young-Ho Park, Yeung Bae Jin, Bong-Hyun Jun, Cheulhee Jung, Dong-Seok Lee*, Sun-Uk Kim*, and Seung Hwan Lee*,
Nucleic Acids Research, 2020, Sep, 48(15), 8601-8616.
[22] Prediction-based highly sensitive CRISPR off-target validation using target-specific DNA enrichment.
Seung-Hun Kang, Wi-jae Lee, Ju-Hyun An, Jong-Hee Lee, Young-Hyun Kim, Hanseop Kim, Yeounsun Oh, Young-Ho Park, Yeung Bae Jin, Bong-Hyun Jun, Junho K Hur*, Sun-Uk Kim* and Seung Hwan Lee*,
Nature communications, 2020, July, 11, 3596 .
[21] Effect of triclosan exposure on developmental competence in parthenogenetic porcine embryo during preimplantation,
Min Ju Kim, Hyo-Jin Park, Sanghoon Lee, Hyo-Gu Kang, Pil-Soo Jeong, Soo Hyun Park, Young-Ho Park, Jong-Hee Lee, Kyung Seob Lim, Seung Hwan Lee, Bo-Woong Sim, Sun-Uk Kim, Seong-Keun Cho, Deog-Bon Koo and Bong-Seok Song, Int J Mol Sci., 2020, 21(16), 5790
In year of 2019
[20] Specificity Assessment of CRISPR Genome Editing of Oncogenic EGFR Point Mutation with Single-Base Differences.
Taegeun Bae#, Hanseop Kim#, Jeong Hee Kim, Yong Jun Kim, Seung Hwan Lee*, Byung-Joo Ham* and Junho K. Hur,
Molecules, 2019, Dec, 25,52 (Co-correspondence)
[19] CRISPR Diagnostics and Therapeutics with Single Base-Pair Precision.
Seung Hwan Lee*, Young-Ho Park, Yeung Bae Jin, Sun-Uk Kim, Junho K Hur*,
Trends in Molecular Medicine, 2019, Nov, 26(3), 337-350 (Co-correspondence)
[18] Comparative evaluation of hormones and hormone-like molecule in lineage specification of human induced pluripotent stem cells.
Seon-A Choi*, Ju-Hyun An*, Seung Hwan Lee*, Geun-Hui Lee, Hae-Jun Yang, Pil-Soo Jeong, Jae-Jin Cha, Sanghoon Lee, Young-Ho Park, Bong-Seok Song, Bo-Woong Sim, Young-Hyun Kim, Ji-Su Kim, Yeung Bae Jin, Jae-Won Huh, Sang-Rae Lee, Jong-Hee Lee, Sun-Uk Kim,
International Journal of Stem Cells, 2019, 12(2), eISSN 2005-5447. (Co-first author)
[17] Real-time PCR quantification of spliced X-box binding protein 1 (XBP1) using a universal primer method,
Seung-Bin Yoon, Young-Ho Park, Seon-A Choi, Hae-Jun Yang, PilSoo Jeong, Jae-Jin Cha, Sanghoon Lee, Seung Hwan Lee, Jong-Hee Lee, BoWoong Sim, Bon-Sang Koo, Sang-Je Park, Youngjeon Lee, Young-Hyun Kim, Jung Joo Hong, Ji-Su Kim, Yeung Bae Jin, Jae-Won Huh, Sang-Rae Lee, BongSeok Song, Sun-Uk Kim,
PLoS One, 2019, 14(7)
In year of 2018
[16] CRISPR/Cas9 searches for a protospacer adjacent motif by lateral diffusion.
Viktorija Globyte#, Seung Hwan Lee#, Taegeun Bae, Jin‐Soo Kim, Chirlmin Joo*,
The EMBO Journal, 2018, Dec, 20. 38(4) e99466. (Co-first author)
[15] CRISPR and Target-Specific DNA Endonucleases for Efficient DNA Knock-in in Eukaryotic Genomes.
Seung Hwan Lee*, Sunghyun Kim, and Junho K Hur*,
Mol. Cells, 2018; 41(11): 943-952. (Co-correspondence)
[14] Direct observation of DNA target searching and cleavage by CRISPR-Cas12a.
Yongmoon Jeon, You Hee Choi, Yunsu Jang, Jihyeon Yu, Jiyoung Goo, Gyejun Lee, You Kyeong Jeong, Seung Hwan Lee, In-San Kim, Jin-Soo Kim, Cherlhyun Jeong, Sanghwa Lee & Sangsu Bae,
Nature Communications, 2018, July 17, volume 9(2777).
In year of 2017
[13] CUT-PCR: CRISPR-mediated, Ultra-sensitive Detection of Target DNA using PCR.
Seung Hwan Lee, Jihyeon Yu, Gue-Ho Hwang, Sojung Kim, Heon Seok Kim, Kyoungmi Kim, Juhee Park, Do Youn Park, Yoon-Kyoung Cho, Jin-Soo Kim, and Sangsu Bae,
Oncogene, 2017, Aug, 28 (36), 6823-6829
[12] Multi-color fluorescence of pNIPAM-Based nanogels modulated by dual stimuli - responsive FRET processes.
Seung Hwan Lee*, Hoa Thi Bui*,Temmy Pegarro Vales, Sung Cho, Ho-Joong Kim,
Dyes and Pigments, 2017, June, 3, 145, 216-221.
[11] Fabrication of Photochromic Hydrogels Using an Interpenetrating Chitosan Networks for Controlled Drug Delivery.
Cheol Woo Lee*, Seung Hwan Lee*, Young-Keun Yang*, Geun-Chang Ryu and Ho-Joong Kim,
Journal of Applied Polymer Science, 2017, Mar, 30, 134(30). 45120-45126. (Co-first author)
[10] Failure to detect DNA-guided genome editing using Natronobacterium gregoryi Argonaute.
Seung Hwan Lee*, Giandomenico Turchiano*, Hirotaka Ata*, Somaira Nowsheen, Marianna Romito, Zhenkun Lou, Seuk-Min Ryu, Stephen C. Ekker, Toni Cathomen, Jin-Soo Kim,
Nature biotechnology, 2017, Jan, 35(1), 17-18.
[9] Light-Induced Fluorescence Modulation of Quantum Dot-Crystal Violet Conjugates: Stochastic Off-On-Off Cycles for Multi-Color Patterning and Super-Resolution.
Sungwook Jung, Joonhyuck Park, Jiwon Bang, Jae-Yeol Kim, Cheolhee Kim, Yongmoon Jeon, Seung Hwan Lee, Ho Jin, Sukyung Choi, Bomi Kim, Woo Jin Lee, Chan-Gi Pack, Jong-Bong Lee, Nam Ki Lee, and Sungjee Kim,
JACS, 2017, May, 139(22), 7603–7615.
[8] Myofibroblast in the Ligamentum Flavum Hypertrophic Activity.
Junseok W. Hur, Taegeun Bae, Sunghyeok Ye, Joo-Hyun Kim, Sunhye Lee, Kyoungmi Kim, Seung Hwan Lee, Jin-Soo Kim, Jang-Bo Lee, Tai-Hyoung Cho, Jung-Yul Park, Junho K. Hur,
European Spine Journal, 2017, Feb, 8, 26(285): 1-10.
[7] Genome surgery using Cas9 ribonucleoproteins for the treatment of age-related macular degeneration.
Kyoungmi Kim, Sung Wook Park, Jin Hyoung Kim, Seung Hwan Lee, Daesik Kim, Taeyoung Koo, Kwang-eun Kim, Jeong Hun Kim, Jin-Soo Kim,
Genome Research, 2017, February 16, 27:419-426.
[6] The bent conformation of poly(A)-binding protein induced by RNA-binding is required for its translational activation function.
Ka Young Hong, Seung Hwan Lee, Sohyun Gu, Eunah Kim, Sihyeon An, Junyoung Kwon, Jong-Bong Lee, Sung Key Jang,
RNA biology, 2017, Mar 4;14(3):370-377.
In year of 2016
[5] Structural and Dynamic views of the CRISPR-Cas System at single-molecule level.
Seung Hwan Lee & Sangsu Bae,
BMB reports, Invited Review, 2016, Apr, 30; 49(4): 201–207.
[4] Structural roles of guide RNA in the nuclease activity of Cas9 endonuclease.
Youngbin Lim, So Young Bak, Keewon Sung, Euihwan Jeong, Seung Hwan Lee, Jin-Soo Kim, Sangsu Bae & Seong Keun Kim,
Nature communications, 2016, Nov. 2, 7, 13350-13357.
In year of 2014
[3] Poly(A) RNA and Paip2 Act as Allosteric Regulators of Poly(A)-Binding Protein.
Seung Hwan Lee, Jungsic Oh, Jonghyun Park, Ki Young Paek, Sangchul Rho, Sung Key Jang, Jong–Bong Lee,
Nucleic Acids Research, 2014 Feb, 42(4), 2697–2707.
[2] Single-molecule Studies of MutS on Mismatched DNA.
Jong–Bong Lee, Won Ki Cho, Jonghyun Park, Yongmoon Jeon, Daehyung Kim, Seung Hwan Lee, R. Fishel,
DNA Repair, Invited Review, 2014, Mar. 12, 20, 82-93.
Before 2014
[1] A novel carbonic anhydrase from the mantle of the pearl oyster (Pinctada fucata).
Zhenyan Yu, Liping Xie, Seung Hwan Lee, Rongqing Zhang,
Comparative Biochemistry and Physiology, Part B, 2006, Jan, 9, 143/2,190-194.
In year of 2025
[40] Directed evolution on compact landing pads yields highly-efficient recombinases for large DNA integration
Hanseop Kim, Hyo-Gu Kang, Yeounsun Oh, Youngjeon Lee, Eun-Kyoung Kim, Ki-Hoan Nam, Dong-Seok Lee, Seung Hwan Lee* and Bo-Woong Sim*
[39] Ultrasensitive single-point mutation detection via digital counting of individual dCas9-DNA complexes. Sensors and Actuators B: Chemical
Seohyun Kim, Wi-jae Lee, Hyomin K. Lee, Sangmin Ji, Junho K. Hur*, Seung Hwan Lee*, Hye Ran Koh*
[38] Optimizing twin prime editing components for scalable genome editing and therapy in spinocerebellar ataxia type 3
Lee Wha Gwon, Jung Bae Seong, Hyeon-Gu Yeo, Yeounsun Oh, Junghyung Park, Jinyoung Won, Sang Je Park, Young-Hyun Kim, Jae-won Huh, Aryun Kim, Youngjeon Lee*, Seung Hwan Lee*
[37] Precise Progerin Targeting Using RfxCas13d: A Therapeutic Avenue for Hutchinson–Gilford Progeria Syndrome, 2025, Molecular Therapy
Unbin Chae †, Hae-Jun Yang †, Hanseop Kim†, Seung Hwan Lee†, Dong Gil Lee, Jeong Young Koo, Seung-min Ha, Seo-Jong Bak, Jin-Man Kim#, Young-Ho Park#, Sun-Uk Kim#
[36] Advances in large-scale DNA engineering with RNA-guided endonucleases, 2025, Experimental & Molecular Medicine
Lee Wha Gwon3,4,*, Isabel Wen Badon1,5,*, Youngjeon Lee3,4, Ho-Joong Kim2,#, Seung Hwan Lee1,#
[35] Optimized and tunable base editing in human-derived cells using an inactivated Cas12b effector, 2025
Wi-jae Lee*, Yun Gyeong Kim*, Yeounsun Oh*, Ho-Joong Kim†, Bo-Woong Sim*, Seung Hwan Lee*
In year of 2024
[34] CdSe Quantum Dot-Based Delivery System for CRISPR-Cas9 Mediated Microglial Gene Modulation, 2024, ACS Applied Nano Materials, Cover
Hyeon-Gu Yeo†, Jinyoung Won†, Lee Wha Gwon†, Seokbeom Roh, Wi-Jae Lee, Kyung Seob Lim, Chang-Yeop Jeon, Junghyung Park, A Reum JE, Jincheol Seo, Jiyeon Cho, Jung Bae Seong, Yu Gyeong Kim, Keonwoo Kim, Sang-Woo Lee, Sung-hyun Park, Won Seok Choi, Yang Hoon Huh, Gyudo Lee, Hyoung-Chin Kim, Seung Hwan Lee*, Youngjeon Lee**
[33] Blood vessel organoids generated by base editing and harboring single nucleotide variation in Notch3 effectively recapitulate CADASIL-related pathogenesis, 2024, Molecular Neurobiology
Yujin Ahn, Ju-Hyun An, Hae-Jun Yang, Wi-Jae Lee, Sang-Hee Lee, Young-Ho Park, Jong-Hee Lee, Hong J. Lee, Seung Hwan Lee*, Sun-Uk Kim*
[32] Tiny CRISPR Molecular Switch Tool Opens a New World, 2024, Molecular Therapy
Yeounsun Oh# & Seung Hwan Lee*
[31] Highly efficient and specific regulation of gene expression using enhanced CRISPR-Cas12f system, 2024, Gene Therapy
Yeounsun Oh, Kee-Pyo Kim* and Seung Hwan Lee*
[30] Recent application of CRISPR-Cas12 and OMEGA system for genome editing, 2023, Molecular Therapy
Isabel Wen Badon, Yeounsun Oh, Ho-Joong Kim*, Seung Hwan Lee*
[29] Recent advances in genome engineering by CRISPR technology, 2024, BMB Reports
Youngsik Lee#, Yeounsun Oh# & Seung Hwan Lee*
[28] Utilization of nicking properties of CRISPR-Cas12a effector for genome editing, 2024, Scientific Reports
Chan Hyoung Kim, Wi-jae Lee, Yeounsun Oh, Youngjeon Lee, Hyomin K. Lee, Jung Bae Seong, Kyung-Seob Lim, Sang Je Park, Jae-Won Huh, Young-Hyun Kim, Kyoung Mi Kim*, Junho K. Hur* and Seung Hwan Lee*
In year of 2022-2023
[27] Highly specific chimeric DNA-RNA guided genome editing with enhanced CRISPR-Cas12a system
Hanseop Kim#, Wi-jae Lee#, Chan Hyoung Kim, Yeounsun Oh, Lee Wha Gwon, Hyomin Lee, Woo Jeung Song, Junho K. Hur, Kyung-Seob Lim, Kang Jin Jeong, Ki-Hoan Nam, Young Suk Won, Kyeong-Ryoon Lee, Youngjeon Lee, Young-Hyun Kim, Jae-Won Huh, Bong-Hyun Jun*, Dong-Seok Lee*, Seung Hwan Lee*,
Molecular Therapy - Nucleic Acids, 2022, June, 28, 353-362.
[26] Expansion of the prime editing modality with Cas9 from Francisella novicida.
Yeounsun Oh#, Wi-jae Lee#, Junho K. Hur#, Woo Jeung Song, Hanseop Kim, Lee Wha Gwon, Young-Hyun Kim, Young-Ho Park, Chan Hyoung Kim, Kyung-Seob Lim, Jae-Won Huh, Sun-Uk Kim, Bong-Hyun Jun, Cheulhee Jung*, Seung Hwan Lee*,
Genome Biology, 2022, April, 23, 92 (2022). https://doi.org/10.1186/s13059-022-02644-8.
In year of 2021
[25] Development of CRISPR technology for precise single-base genome editing: a brief review.
Hyomin K. Lee#, Yeounsun Oh#, Juyoung Hong, Seung Hwan Lee*, Junho K. Hur*,
BMB Reports, 2021, Feb, 54(2):98-105
[24] Peroxiredoxin-6 regulates p38-mediated epithelial–mesenchymal transition in HCT116 colon cancer cells
Unbin Chae, Bokyung Kim, HanSeop Kim, Young‑Ho Park, Seung Hwan Lee, Sun‑Uk Kim and Dong‑Seok Lee,
Journal of Biological Research-Thessaloniki, 2021, 2021 Nov 23;28(1):22.
In year of 2020
[23] Enhancement of Target Specificity of CRISPR-Cas12a by Using a Chimeric DNA-RNA Guide.
Hanseop Kim#, Wi-jae Lee#, Yeounsun Oh, Seung-Hun Kang, Junho K. Hur, Hyomin Lee, WooJeung Song, Kyung-Seob Lim, Young-Ho Park, Yeung Bae Jin, Bong-Hyun Jun, Cheulhee Jung, Dong-Seok Lee*, Sun-Uk Kim*, and Seung Hwan Lee*,
Nucleic Acids Research, 2020, Sep, 48(15), 8601-8616.
[22] Prediction-based highly sensitive CRISPR off-target validation using target-specific DNA enrichment.
Seung-Hun Kang, Wi-jae Lee, Ju-Hyun An, Jong-Hee Lee, Young-Hyun Kim, Hanseop Kim, Yeounsun Oh, Young-Ho Park, Yeung Bae Jin, Bong-Hyun Jun, Junho K Hur*, Sun-Uk Kim* and Seung Hwan Lee*,
Nature communications, 2020, July, 11, 3596 .
[21] Effect of triclosan exposure on developmental competence in parthenogenetic porcine embryo during preimplantation,
Min Ju Kim, Hyo-Jin Park, Sanghoon Lee, Hyo-Gu Kang, Pil-Soo Jeong, Soo Hyun Park, Young-Ho Park, Jong-Hee Lee, Kyung Seob Lim, Seung Hwan Lee, Bo-Woong Sim, Sun-Uk Kim, Seong-Keun Cho, Deog-Bon Koo and Bong-Seok Song, Int J Mol Sci., 2020, 21(16), 5790
In year of 2022-2023
[27] Highly specific chimeric DNA-RNA guided genome editing with enhanced CRISPR-Cas12a system
Hanseop Kim#, Wi-jae Lee#, Chan Hyoung Kim, Yeounsun Oh, Lee Wha Gwon, Hyomin Lee, Woo Jeung Song, Junho K. Hur, Kyung-Seob Lim, Kang Jin Jeong, Ki-Hoan Nam, Young Suk Won, Kyeong-Ryoon Lee, Youngjeon Lee, Young-Hyun Kim, Jae-Won Huh, Bong-Hyun Jun*, Dong-Seok Lee*, Seung Hwan Lee*,
Molecular Therapy - Nucleic Acids, 2022, June, 28, 353-362.
[26] Expansion of the prime editing modality with Cas9 from Francisella novicida.
Yeounsun Oh#, Wi-jae Lee#, Junho K. Hur#, Woo Jeung Song, Hanseop Kim, Lee Wha Gwon, Young-Hyun Kim, Young-Ho Park, Chan Hyoung Kim, Kyung-Seob Lim, Jae-Won Huh, Sun-Uk Kim, Bong-Hyun Jun, Cheulhee Jung*, Seung Hwan Lee*,
Genome Biology, 2022, April, 23, 92 (2022). https://doi.org/10.1186/s13059-022-02644-8.
In year of 2021
[25] Development of CRISPR technology for precise single-base genome editing: a brief review.
Hyomin K. Lee#, Yeounsun Oh#, Juyoung Hong, Seung Hwan Lee*, Junho K. Hur*,
BMB Reports, 2021, Feb, 54(2):98-105
[24] Peroxiredoxin-6 regulates p38-mediated epithelial–mesenchymal transition in HCT116 colon cancer cells
Unbin Chae, Bokyung Kim, HanSeop Kim, Young‑Ho Park, Seung Hwan Lee, Sun‑Uk Kim and Dong‑Seok Lee,
Journal of Biological Research-Thessaloniki, 2021, 2021 Nov 23;28(1):22.
In year of 2020
[23] Enhancement of Target Specificity of CRISPR-Cas12a by Using a Chimeric DNA-RNA Guide.
Hanseop Kim#, Wi-jae Lee#, Yeounsun Oh, Seung-Hun Kang, Junho K. Hur, Hyomin Lee, WooJeung Song, Kyung-Seob Lim, Young-Ho Park, Yeung Bae Jin, Bong-Hyun Jun, Cheulhee Jung, Dong-Seok Lee*, Sun-Uk Kim*, and Seung Hwan Lee*,
Nucleic Acids Research, 2020, Sep, 48(15), 8601-8616.
[22] Prediction-based highly sensitive CRISPR off-target validation using target-specific DNA enrichment.
Seung-Hun Kang, Wi-jae Lee, Ju-Hyun An, Jong-Hee Lee, Young-Hyun Kim, Hanseop Kim, Yeounsun Oh, Young-Ho Park, Yeung Bae Jin, Bong-Hyun Jun, Junho K Hur*, Sun-Uk Kim* and Seung Hwan Lee*,
Nature communications, 2020, July, 11, 3596 .
[21] Effect of triclosan exposure on developmental competence in parthenogenetic porcine embryo during preimplantation,
Min Ju Kim, Hyo-Jin Park, Sanghoon Lee, Hyo-Gu Kang, Pil-Soo Jeong, Soo Hyun Park, Young-Ho Park, Jong-Hee Lee, Kyung Seob Lim, Seung Hwan Lee, Bo-Woong Sim, Sun-Uk Kim, Seong-Keun Cho, Deog-Bon Koo and Bong-Seok Song, Int J Mol Sci., 2020, 21(16), 5790